08:57 uur 26-11-2019

GN CORPORATION: gezichtsvermogen hersteld met hoornvliesceltransplantatie met behulp van een nanoplaattechniek; Japans bedrijf patent verleend in India

TOKIO– (BUSINESS WIRE) – Een nieuwe celtransplantatiemethode voor de behandeling van cornea-endotheelziekten zoals bulleuze keratopathie met behulp van een nanocomposietgelplaat ontwikkeld door Japanse wetenschappers, kreeg het Indiase patent van GN Corporation (GNC), Japan. Aan deze methode werd eerder een Japans patent verleend, waarbij één kadaver-donor-hoornvliescellen konden worden gebruikt om het zicht op de ogen van verschillende patiënten te redden met behulp van in het laboratorium gekweekte cornea-endotheliale voorlopercellen.

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Endotheelziekten van het hoornvlies als gevolg van trauma, inclusief onbedoeld chirurgisch trauma tijdens staarprocedures treffen ongeveer 30.000 patiënten in India en miljoenen wereldwijd. Elk jaar waarvoor de endotheliale laag van het hoornvlies van een kadaver-donor moet worden getransplanteerd en het maken van één kadaver-donoroog redt één oog van een patiënt. In deze context,  wordt bij oogbanken wereldwijd 30% van de donor-hoornvliezen weggegooid die ongeschikt worden geacht voor transplantatie vanwege een onvoldoende aantal endotheelcellen. De technologie van GNC haalt de beschikbare cellen op, in het anders weggegooide donor-hoornvlies en verandert ze in bruikbare hulpmiddelen voor het herstel van het gezichtsvermogen na vermenigvuldiging in het laboratorium om verschillende ogen te redden van patiënten die wachten op transplantatie, genaamd “An-eye for Eyes” -missie

GN CORPORATION: Vision Restored with Corneal Cell Transplant Using a Nano Sheet Technique; Japanese Firm Granted Patent in India

TOKYO–(BUSINESS WIRE)– A novel cell transplantation method to treat corneal endothelial diseases such as bullous keratopathy using a nano-composite gel sheet developed by Japanese scientists was granted Indian patent to GN Corporation (GNC), Japan. This method was earlier granted a Japanese patent, in which one cadaver donor cornea derived cells could be used to save vision of several patients’ eyes using lab grown corneal endothelial precursor cells.

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Corneal endothelial cell transplantation for Bullous Keratopathy from lab to clinical translation using polymer cocktails and nano-composite gel sheet (Graphic: Business Wire)

Corneal endothelial cell transplantation for Bullous Keratopathy from lab to clinical translation using polymer cocktails and nano-composite gel sheet (Graphic: Business Wire)

Corneal endothelial diseases due to trauma including inadvertent surgical trauma during cataract procedures affect approximately 30,000 patients in India and millions globally, every year for which either corneal endothelial layer or the full cornea from cadaver-donor must be transplanted, making one cadaver-donor eye save one eye of a patient. In this background, eye banks world over discard 30% of donor-corneas deemed unfit for transplant due to inadequate number of endothelial cells. GNC’s technology retrieves the available cells in the otherwise discarded donor cornea and turns them into usable tools for restoring vision after multiplication in the lab to save several eyes of patients waiting for transplant, named as “An-eye for Eyes” mission.

Major hurdle towards a clinical translation was with the cell transplantation procedure. In earlier attempts of cell transplantation by several groups worldwide, the patient had to lie in eye-down position for long hours, enable the cells injected into the anterior chamber of the eye, settle at the site of endothelial damage and help repair the disease affected endothelium of cornea. The present accomplishment has used a novel nano composite gel sheet, thereby avoiding such inconvenient eye-down posture to patients as it enabled successful engraftment in animal eyes and similar work in a human pilot study has been proven effective in which one donor-cornea derived cells could be used to help restore the vision of three patients (Am J Stem Cells, 2018).

GNC has partnered with JBM Inc., & Edogawa Evolutionary Laboratory of Science, Tokyo to set up a nanomaterial development facility to produce this nano-composite gel sheet and are open for collaboration with both academic and industry partners in propagating this technique globally. Patients in developing nations where the corneal donor grafts are inadequate to meet the need for patients with corneal diseases waiting for transplantation, will be benefitted by this technique according to the inventors.

Contacts

Queries to:

GN Corporation

Samuel JK Abraham

info@gncorporation.com

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