10:07 uur 29-05-2018

Grote Studie Biedt Eerste Inzicht ooit in de Genetische oorzaken van Bedplassen

SAINT-PREX, Zwitserland – (BUSINESS WIRE) –

– Het is waarschijnlijk erfelijk: kinderen van wie de ouders het bed nat maken zijn eerder bedplassen

– Het eerste genoombrede verenigingsonderzoek (GWAS) in bedplassen identificeert specifieke genetische varianten die het risico op bedplassen vergroten.

– Een verdere afbakening van de genetische component van bedplassen zou kunnen helpen bij het identificeren van kinderen die vatbaar zijn voor bedplassen en leiden tot een behandeling op maat.

Nieuw bewijsmateriaal uit de eerste genoombrede studie ter wereld (GWAS) identificeert genen en genetische varianten die verband houden met bedplassen en kan leiden tot een snellere identificatie van kinderen die aanleg hebben voor bedplassen en tot verbeterde eerdere behandelingsopties. Op Wereld Bedplas Dag 29 mei 2018 presenteert de International Children’s Continence Society (ICCS) en de European Society for Paediatric Urology (ESPU) de resultaten.

“We weten al meer dan een eeuw dat er sterke aanwijzingen zijn dat er een genetische achtergrond is voor bedplassen. Het risico op bedplassen is 5-7 keer hoger bij kinderen met een ouder die als kind aan bedplassen leed, en ongeveer 11 keer hoger als beide ouders bedplassers waren”, vertelde Dr. Søren Rittig, professor aan de Afdeling Kind en Jeugd, Neuro-urologisch Team, van het Universitair Ziekenhuis in Aarhus die samen met zijn collega, professor Jane Hvarregaard Christensen, Afdeling medische biologie, Universiteit Aarhus, verantwoordelijk waren voor deze nieuwe studie.

Voor meer informatie: www.worldbedwettingday.com.

Large-Scale Study Provides First-Ever Insights into the Genetic Causes of Bedwetting

SAINT-PREX, Switzerland–(BUSINESS WIRE)–

It is likely to be hereditary: children whose parents wet the bed are more likely to be bedwetters1

The world’s first genome-wide association study (GWAS) in bedwetting identify specific genetic variants that increase the risk of bedwetting

Further delineation of the genetic component of bedwetting could help to identify children predisposed to bedwetting and lead to better tailored treatment

New evidence from the world’s first genome-wide association study (GWAS) identifies genes and genetic variants associated with bedwetting and may lead to earlier identification of children predisposed to bedwetting and improved earlier treatment options.The results are being presented by the International Children’s Continence Society (ICCS) and the European Society for Paediatric Urology (ESPU) on World Bedwetting Day on 29 May 2018.

“We have known for over a century, there has been strong evidence suggesting a genetic background for bedwetting.2 The risk of bedwetting is 5-7 times higher among children with a parent who suffered from bedwetting as a child, and approximately 11 times higher if both parents were bedwetters”,1 said Dr. Søren Rittig, Professor at the Department of Child and Youth, Nephro-urologic Team, Aarhus University Hospital who together with associate professor Jane Hvarregaard Christensen, Department of Biomedicine, Aarhus University is responsible for this new study.

Bedwetting is a common medical condition that has a serious impact on a child’s self-esteem, emotional well-being and day time functioning, including school and social performance3,4,5; and improvements in their working memory and other daily activities have been seen after treatment.6

The GWAS used the iPSYCH2012 nationwide population-based sample of around 80,000 Danish individuals collected to study among others ADHD and autism. Genome-wide association studies work by scanning markers across the entire genome of large numbers of people in order to find genetic variants associated with a particular disease.

Associate professor Jane Hvarregaard Christensen said, “By comparing the frequency of millions of genetic variants in thousands of DNA samples from bedwetting children we have been able to demonstrate specific genetic variants that each contribute to increase the risk of bedwetting. The genes implicated by this are known to function in deep brain areas responsible for regulation of day-night rhythms, urine production and sleep. This supports that bedwetting is linked to physiological mechanisms rather than being caused by psychological problems.” This is an important first step to provide new insights into the biological processes leading to bedwetting.

There are at least two main reasons why children are bedwetting – a reduced bladder capacity and/or an increased urine production during night-time (polyuria). By analyzing millions of genetic variants in bedwetting children, researchers were able to point to specific genes and thereby suggest specific biological causes of bedwetting.

Dr. Søren Rittig said, “We believe further research using the genes and genetic variants we have detected could help us identify bedwetting children earlier, determine which children would benefit from medication and tailor treatment to alleviate their condition.”

About Bedwetting

Bedwetting, also known as nocturnal enuresis, is an uncontrollable leakage of urine while asleep.7 In most cases it is caused by over-production of urine at night or reduced capacity of the bladder.4 An inability to wake up can be another cause.4 Bedwetting does not seem to have a psychological cause.4 Bedwetting is a common childhood medical condition, with approximately 5–10% of 7-year-olds regularly wetting their beds and the problem may persist into teenage and adulthood.8

About World Bedwetting Day

World Bedwetting Day was initiated to raise awareness among the public and healthcare professionals that bedwetting is a common medical condition that can and should be treated.

World Bedwetting Day 2018 will take place on 29 May and occurs on the last Tuesday of May each year. The theme is: ‘Time to Take Action’, in recognition that much more can be done to diagnose and treat those children who suffer from bedwetting.

For more information please visit www.worldbedwettingday.com.

About the World Bedwetting Day Steering Committee

The World Bedwetting Day Steering Committee brings together experts from across the globe to support this initiative and consists of the International Children’s Continence Society (ICCS), the European Society of Paediatric Urology (ESPU), the Asia Pacific Association of Paediatric Urology (APAPU), the International Paediatric Nephrology Association (IPNA), the European Society of Paediatric Nephrology (ESPN), the Sociedad Iberoamericana de Urologia Paediatrica (SIUP), and the North American Paediatric Urology Societies. The initiative is supported by Ferring Pharmaceuticals.

References

1 Jarvelin, M. R., Vikevainen-Tervonen, L., Moilanen, I. & Huttunen, N. P. Enuresis in seven-year-old children. Acta paediatrica Scandinavica 77, 148-153 (1988).
2 von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, H. & Rittig, S. The genetics of enuresis: a review. The Journal of urology 166, 2438-2443 (2001).
3 Iannelli V. Bedwetting. Available at https://www.verywell.com/bedwetting-bedwetting-statistics-2633257. Last accessed January 2017.
4 Vande Walle J et al, Practical consensus guidelines for the management of enuresis. Eur J Pediatr 2012;171:971-98
5 Joinson C et al. A United Kingdom population-based study of intellectual capacities in children with and without soiling, daytime wetting, and bed-wetting Pediatrics. 2007;120(2):e308-16
6 Van Herzeele C, Dhondt K, Roels S P et al. Desmopressin (melt) therapy in children with monosymptomatic nocturnal enuresis and nocturnal polyuria results in improved neuropsychological functioning and sleep. Pediatr Nephrol. 2016; DOI 10.1007/s00467-016-23351-3
7 Austin P et al. The Standardization of Terminology of Lower Urinary Tract Function in Children and Adolescents: Update Report from the Standardization Committee of the International Children’s Continence Society, The Journal of Urology. 2014;191:1863-1865
8 Nevéus T. Nocturnal enuresis—theoretic background and practical guidelines. Pediatr Nephrol. 2011; 26:1207–1214

 

Contacts

Burson-Marsteller, on behalf of World Bedwetting Day Steering Committee
Jack Dixey, +44 (0)207 300 6221
Jack.Dixey@bm.com

Deze bekendmaking is officieel geldend in de originele brontaal. Vertalingen zijn slechts als leeshulp bedoeld en moeten worden vergeleken met de tekst in de brontaal, die als enige rechtsgeldig is. Check out our twitter: @NewsNovumpr