07:38 uur 05-08-2020

Asahi Kasei levert monsters van hyaluronic acid nanogel als een nieuw farmaceutisch hulpmiddel

Op weg naar commercialisering als basismateriaal voor systemen voor medicijnafgifte

TOKIO– (BUSINESS WIRE) – Asahi Kasei heeft industriële fabricagetechnologie voor hyaluronic acid (HA) nanogel * ontwikkeld als een nieuw farmaceutisch hulpmiddel en levert monsters aan potentiële klanten om het product te commercialiseren.

Dit persbericht bevat multimedia. Bekijk hier de volledige release: https://www.businesswire.com/news/home/20200804005334/en/

De Functional Additives Division van Asahi Kasei’s Specialty Solutions SBU supplies levert Ceolus ™ microkristallijne cellulose aan farmaceutische fabrikanten over de hele wereld voor gebruik als hulpmiddel voor drugstabletten. De commercialisering van HA nanogel zou de productlijn uitbreiden door een drug delivery system (DDS) basismateriaal voor injectieformuleringen toe te voegen.

Asahi Kasei Providing Samples of Hyaluronic Acid Nanogel as a New Pharmaceutical Excipient

Advancing toward commercialization as base material for drug delivery systems

TOKYO–(BUSINESS WIRE)– Asahi Kasei has established industrial manufacturing technology for hyaluronic acid (HA) nanogel* as a new pharmaceutical excipient, and is providing samples to prospective customers in order to commercialize the product.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20200804005334/en/

Chemical structure and self-assembly of HA nanogel (Graphic: Business Wire)

Chemical structure and self-assembly of HA nanogel (Graphic: Business Wire)

The Functional Additives Division of Asahi Kasei’s Specialty Solutions SBU supplies Ceolus™ microcrystalline cellulose to pharmaceutical manufacturers around the world for use as an excipient for drug tablets. The commercialization of HA nanogel would expand the product lineup by adding a drug delivery system (DDS) base material for injection formulations.

HA nanogel is expected to improve the quality of life (QOL) for patients by enabling the low-toxicity solubilization of insoluble drugs, facilitating the formulation of biopharmaceuticals such as proteins and peptides by suppressing their aggregation and denaturation, and reducing the frequency of injection when repeated administration is required.

Characteristics of the new HA nanogel:


HA nanogel is derived by the partial modification of hyaluronic acid with cholesterol. In water, self-association occurs among the cholesterol portions due to hydrophobic interaction, causing the formation of nanometer-scale hydrogel. The physical properties of HA nanogel depend on the molecular weight of HA and the cholesterol modification rate. Two grades of samples, a dispersion grade and a precipitation grade, are currently available.


The hydrophobic interaction enables a wide variety of insoluble drugs, ranging from low and medium molecular weight (MW) compounds to proteins, to be enclosed in the nanogel by simple mixing. This makes HA nanogel suitable for use as a base material for DDS. The main functions are sustained release, solubilization, suppression of aggregation, and retention of drug activity. Grades can be optimized to match specific customer requirements.

Asahi Kasei will make a formal decision on the commercialization of HA nanogel after confirming that the provided samples have contributed to solutions for the development of drug formulations by customers.

Asahi Kasei remains committed to meeting the needs of customers through products that contribute to life and living for people around the world.

Inquiries regarding HA nanogel samples should be directed to:

New Product Development Office

Functional Additives Division

Specialty Solutions SBU

Asahi Kasei Corp.


* Asahi Kasei has an exclusive license for HA nanogel technology developed by Chugai Pharmaceutical Co., Ltd.


For more information, please contact:
Specialty Solutions SBU

Functional Additives Division

Yurika Tanaka

Phone: +81-(0)3-6699-6863

Asahi Kasei Corp.

Corporate Communications

Phone: +81-(0)3-6699-3008

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